![]() ![]() Thus the maintenance of the intracellular K + concentration is a dynamic and fundamental process involving Na +-K +-ATPase ( 8). Hydrolysis of ATP by Na +-K +-ATPase fuels the coupled transport of K + into the cell and Na + out of the cell. ![]() In addition to these general functions, Na +-K +-ATPase promotes membrane repolarization and reuptake of extracellular potassium in excitable cells, including skeletal muscle ( 8). Na +- k +- atpase is a membrane cation pump that is critically involved in the maintenance of intracellular sodium and potassium concentrations and participates in the maintenance of cell volume and electrochemical gradients. An understanding of the molecular regulation of Na +-K +-ATPase in skeletal muscle will have important clinical implications for the understanding of the development of complications associated with the metabolic syndrome, such as cardiovascular diseases or increased muscle fatigue in diabetic patients. ![]() Furthermore, the methodological caveats of major approaches to study the sodium pump translocation in skeletal muscle are discussed. This review summarizes more than 30 years work on the skeletal muscle sodium pump translocation paradigm. Due to the contradictory reports in the literature, the very existence of the translocation of Na +-K +-ATPase to the skeletal muscle cell surface is questionable. The molecular mechanism of this phenomenon is poorly understood. ![]() Insulin and muscle contractions stimulate Na +-K +-ATPase activity in skeletal muscle, at least partially via translocation of sodium pump units to the plasma membrane from intracellular stores. The skeletal muscle sodium pump plays a major role in the removal of K + ions from the circulation postprandial, or after a physical activity bout, thereby preventing the development of hyperkalemia and fatigue. ![]()
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